RAS p21 protein activator 1 - Wikipedia
WEBRAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120- kDa cytosolic human protein that provides two principal activities: Inactivation of Ras from its active GTP -bound form to its inactive GDP -bound form by enhancing the endogenous GTPase activity of Ras, via its C-terminal GAP domain.
Anti-cancer peptides from ras-p21 and p53 proteins - PubMed
WEBWe have employed computer-based molecular modeling approaches to design peptides from the ras-p21 and p53 proteins that either induce tumor cell reversion to the untransformed phenotype or induce tumor cell necrosis without affecting normal cells. For rasp21, we have computed and superimposed the av …
Role of RASA1 in cancer: A review and update (Review) - PubMed
WEBRas p21 protein activator 1 (RASA1) is a regulator of Ras GDP and GTP and is involved in numerous physiological processes such as angiogenesis, cell proliferation, and apoptosis. As a result, RASA1 also contributes to pathological processes in vascular diseases and tumour formation.
Novel peptides from the RAS-p21 and p53 proteins for the …
WEBRemarkably, we have found that two ras-p21 peptides, 35–47 and 96–110, called PNC-7 and PNC-2, respectively, can induce phenotypic reversion of ras-transformed TUC-3 pancreatic cancer cells and ras-transformed HT1080 human fibrosarcoma cells to their untransformed phenotypes.
Peptides That Block RAS-p21 Protein-Induced Cell Transformation
WEBFeb 6, 2023 · This is a review of approaches to the design of peptides and small molecules that selectively block the oncogenic RAS-p21 protein in ras-induced cancers. Single amino acid substitutions in this protein, at critical positions such as at Gly 12 and Gln 61, cause the protein to become oncogenic. These mutant proteins cause over 90 percent of ...
The p21-Ras signal transduction pathway and growth
WEBApr 1, 1999 · Introduction. Gliomas are the most frequent primary intraaxial mass in the adult 182, 255 and pediatric 26, 57 brain. Constituting 50% to 55% of all gliomas (and approximately 25% of all intracranial tumors), glioblastoma multiforme (GBM) is the most common variety, nearly twice as frequent as the anaplastic astrocytoma.
Elevated serum RAS p21 is an independent prognostic factor in ...
WEBMay 8, 2018 · RAS p21 was measured in samples from 34 newly diagnosed early breast cancer patients, 26 women with benign breast disease and 34 healthy women. RAS p21 was detected in 53% of cancer cases, 27% of women with benign lesions and 26% of the healthy controls.
Peptides designed from molecular modeling studies of the
WEBMay 29, 2003 · From molecular modeling studies we found that two ras-p21 peptides, corresponding to p21 residues 35–47 (PNC-7) and 96–110 (PNC-2), selectively.
Anti-cancer Peptides from Ras-P21 and P53 Proteins
WEBJul 5, 2011 · Humans have three Ras genes, H-Ras, K-Ras and N-Ras that are distributed on different chromosomes, encoding protein p21 (23, 24). Ras-p21 binds to guanine nucleotides (GTP and GDP) and the GTP ...
Inhibitory effect of flavonoids on mutant H-Rasp21 protein
WEBJun 15, 2010 · Mutant form of H-Ras (Harvey-Ras) proteins are found in almost 10%-25% of human tumours. Mutational activation transforms it into an oncogenic form, which results in the loss of intrinsic GTPase function and therefore the protein is constitutively in the active, GTP-bound state and is continuously sending signals for cell growth and proliferation.
Skip to content