Hallmarks of T cell aging - Nature Immunology
网页2021年5月13日 · The hallmarks of T cell aging can be grouped into three distinct categories, based on their hierarchical interconnections. Four primary hallmarks (thymic involution, mitochondrial dysfunction ...
The role of T cells in age-related diseases - Nature
网页2021年6月8日 · We present different mechanisms by which T cells contribute to inflammageing and might act as modulators of age-associated diseases, including through enhanced pro-inflammatory and cytotoxic ...
Age-associated remodeling of T cell immunity and metabolism - Cell …
网页2022年12月5日 · Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and cellular metabolism critically affect the development, maintenance, and function of T cells.
Aging promotes reorganization of the CD4 T cell landscape …
网页In the current study, we aimed to comprehensively describe how the CD4 T cell compartment is sculptured during the process of aging. Our scRNA-seq and flow cytometry data, together with the functional assays we performed, allowed in-depth characterization of CD4 T cell subsets in aging.
Mechanisms underlying T cell ageing - Nature Reviews Immunology
网页2019年6月11日 · T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and cancer and in impairing the response to vaccination.
Hallmarks of T cell aging - PubMed
网页Recent evidence indicates that CD4 + T cell-intrinsic alteratins contribute to chronic inflammation and are sufficient to accelerate an organism-wide aging phenotype, supporting the idea that T cell aging plays a major role in body-wide deterioration. In this Review, we propose ten molecular hallmarks to represent common denominators of T cell ...
Hallmarks of the aging T cell system - PMC - National Center for ...
网页The T cell system has to meet the challenge to preserve a diverse population capable of self-renewal while rapidly responding and differentiating upon pathogen encounter. T cell aging is a combination of failure to maintain this balance and lack of adaptation to a changing environment in the host while dealing with aging-related cellular defects.
Mechanisms underlying T cell ageing - PMC - National Center for ...
网页T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and cancer and in impairing responses to vaccinations.
T cell ageing: Effects of age on development, survival & function
网页A steady decline in the production of fresh naïve T cells, more restricted T cell receptor (TCR) repertoire and weak activation of T cells are some of the effects of ageing. In this review we summarize our present understanding of the effects of ageing on naïve CD4 T cells and potential approaches for therapeutic interventions to restore ...
Age-associated remodeling of T cell immunity and metabolism
网页2023年1月3日 · In this review, we summarize recent advances in our understanding of aged T cell metabolism, with a focus on the bioenergetic and immunologic features of T cell subsets unique to the aging process. We also survey insights into mechanisms of metabolic T cell dysfunction in aging and discuss the impacts of aging on the efficacy of cancer ...