SCF complex - Wikipedia
网页Skp, Cullin, F-box containing complex (or SCF complex) is a multi-protein E3 ubiquitin ligase complex that catalyzes the ubiquitination of proteins destined for 26S proteasomal degradation. [1] Along with the anaphase-promoting complex, [2] SCF has important roles in the ubiquitination of proteins involved in the cell cycle.
The SCF ubiquitin ligase: insights into a molecular machine
网页2004年9月1日 · The SCF complex is a multi-subunit ubiquitin ligase that specifically transfers activated ubiquitin to target-protein substrates. SCF is named after...
The SCF Complex Is Essential to Maintain Genome and …
网页2021年8月9日 · The SKP1, CUL1, F-box protein (SCF) complex encompasses a group of 69 SCF E3 ubiquitin ligase complexes that primarily modify protein substrates with poly-ubiquitin chains to target them for proteasomal degradation. These SCF complexes are distinguishable by variable F-box proteins, which determine substrate specificity.
The Biology of F-box Proteins: The SCF Family of E3 Ubiquitin ... - PubMed
网页Here, we provide an introduction to the discovery and classification of F-box proteins, the overall structural assembly of SCF complexes, the varied mechanisms by which F-box proteins recognize their substrates, and the role F-box proteins play in diseases and their potentials in targeted therapies.
The role of SCF ubiquitin-ligase complex at the beginning of life
网页2019年11月28日 · We review the biological roles of the SCF ubiquitin-ligase complex in gametogenesis, oocyte-to-embryo transition, embryo development and the regulation for estrogen and progestin.
E3 ubiquitin ligases: styles, structures and functions - PMC
网页2021年7月30日 · SCF E3 ligases are the largest E3 ligases complex, including Skp1, Cullin1 and F-box proteins . These proteins connect with each other and perform distinct functions. F-box is crucial for the recognition of the substrates. Skp1 is responsible for binding the catalytic core of the SCF complex to the F-box motif.
The SCF Complex Is Essential to Maintain Genome and …
网页2021年8月9日 · Further characterization of the SCF complex functions is essential to identify and develop therapeutic approaches to exploit aberrant SCF complex expression and function. The SKP1, CUL1, F-box protein (SCF) complex encompasses a group of 69 SCF E3 ubiquitin ligase complexes that primarily modify protein substrates with poly-ubiquitin chains to ...
Ubiquitin ligation to F-box protein targets by SCF–RBR E3
网页2021年2月3日 · After neddylation of a substrate-bound SCF E3, the RING domain of RBX1 and NEDD8 could co-contact an autoinhibited ARIH1–UBE2L3~ubiquitin complex. The Ariadne domain of ARIH1 twists upon...
SCF Complex - an overview | ScienceDirect Topics
网页The SCF complex (Fig. II) consists of four major components: Skp1, Cul1/Cdc53, Roc1/Rbx1/Hrt1, and an F-box protein. Cul1 is a scaffold protein; its C-terminus interacts with Roc1, which contains a characteristic RING-finger domain to recruit Ub–E2; the N-terminus interacts with Skp1, which binds the conserved F-box domain of an F-box protein.
Systemwide disassembly and assembly of SCF ubiquitin ligase …
网页2023年4月6日 · Cells respond to environmental cues by remodeling their inventories of multiprotein complexes. Cellular repertoires of SCF (SKP1-CUL1-F box protein) ubiquitin ligase complexes, which mediate much protein degradation, require CAND1 to distribute the limiting CUL1 subunit across the family of ∼70 different F box proteins.
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