ROMK - Wikipedia
网页The renal outer medullary potassium channel (ROMK) is an ATP-dependent potassium channel (K ir 1.1) that transports potassium out of cells. It plays an important role in potassium recycling in the thick ascending limb (TAL) and potassium secretion in the cortical collecting duct (CCD) of the nephron .
A comprehensive guide to the ROMK potassium channel: form …
网页2009年5月20日 · ROMK encodes a major potassium secretory channel in the kidney. In distal nephron principal cells, ROMK1 and ROMK3 form the predominant 30-pS potassium channel. The high density and activity of these channels …
A comprehensive guide to the ROMK potassium channel: form and ... - PubMed
网页Here we provide a comprehensive guide to ROMK, spanning from the physiology in the kidney to the organization and regulation by intracellular factors to the structural basis of its function at the atomic level.
肾小管顶端膜ROMK 通道的功能及调控 - 生理科学进展
网页肾外髓钾通道 (renal outer medullary potassium channel, ROMK)是内向整流钾通道超家族成员,介导肾小管上皮细胞内K+ 向小管腔的转运,在维持机体钾稳态方面发挥重要作用。. 其编码基因突变可引起肾功能受损,呈现以K+ 代谢紊乱为特点的II型Bartter's综合征,故ROMK 通道功 …
教材质疑 | 低镁血症引起低钾血症是何因？ - 丁香园
网页2018年1月14日 · 这个 ROMK，即 the renal outer-medullary K+ channel，是今天要说的一个重要结构，有个很拗口的中文名称：肾脏外髓钾通道。. 也有称之为 KIR1.1，学名应该是：potassium voltage-gated channel subfamily J member 1，感兴趣的可以看看这方面更多的文献。. Na+通过 ENaC（绿色圆柱体 ...
Regulation of Potassium Homeostasis - PMC - National Center for ...
网页2015年6月5日 · The apically located renal outer medullary K + (ROMK) channel provides a pathway for K + to recycle from cell to lumen, and ensures an adequate supply of K + to sustain Na +-K +-2Cl − cotransport. This movement through ROMK creates a lumen-positive voltage, providing a driving force for passive K + reabsorption through the …
The Renal Outer Medullary Potassium Channel (ROMK): An
网页In recent years, understanding of the physiological role of the renal outer medullary potassium (ROMK) channels, has shown an intriguing pharmacological target for developing an innovative class of diuretic agents: the ROMK inhibitors.
ROMK - an overview | ScienceDirect Topics
网页Renal outer medullary potassium (ROMK) was the first identified member 1 of the inwardly rectifying family of potassium (K ir) channels, which include seven subfamilies (K ir 1–7) that differ in tissue distribution, strength of rectification, and in their regulation. 2 K ir channels are tetramers comprising four identical or related subunits ...
离子通道学说-内向整流钾通道ik1 - 哔哩哔哩
网页2022年3月15日 · 其中就包括肾脏上的kir1.1,也就是主细胞上的肾外髓钾通道(ROMK)。 我们知道外科书上有这样一句话，再给顽固性低钾血症输钾效果不明显时要补镁。 那又是为什么呢？
ENaC and ROMK channels in the connecting tubule regulate renal K
网页2021年8月8日 · We measured the activities of epithelial Na channels (ENaC) and ROMK channels in the distal nephron of the mouse kidney and assessed their role in the process of K + secretion under different physiological conditions. Under basal dietary conditions (0.5% K), ENaC activity, measured as amiloride-sensitive currents, was high in cells at the ...
- 某些结果已被删除