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p21 - Wikipedia
WEBp21 is a potent cyclin-dependent kinase inhibitor (CKI). The p21 (CIP1/WAF1) protein binds to and inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4 /6 complexes, and thus functions as a regulator of cell cycle progression at G 1 and S phase.
Multiple functions of p21 in cell cycle, apoptosis and ... - PubMed
WEBCyclin-dependent kinase (CDK) inhibitor p21 (also known as p21 (WAF1/Cip1)) is one of these factors that promote cell cycle arrest in response to a variety of stimuli. The inhibitory effect of P21 on cell cycle progression correlates with its nuclear localization.
p21 in cancer: intricate networks and multiple activities
WEBMay 14, 2009 · The cyclin-dependent kinase inhibitor p21 (also known as p21 WAF1/Cip1) promotes cell cycle arrest in response to many stimuli. It is well positioned to function as both a sensor and an...
Review Multiple functions of p21 in cell cycle, apoptosis and ...
WEBJun 1, 2016 · The inhibitory effect of P21 on cell cycle progression correlates with its nuclear localization. P21 can be induced by both p53-dependent and p53-independent mechanisms. Some other important functions attributed to p21 include transcriptional regulation, modulation or inhibition of apoptosis.
What is the Effect of P21 in Cellular Function? - News-Medical.net
WEBFeb 3, 2020 · Cyclin-dependent kinase inhibitor 1, also known as CDK-interacting protein 1, or more simply as p21, is a cell cycle inhibitor that promotes both CDK/cyclin inhibition as well as cell...
P21 - an overview | ScienceDirect Topics
WEBp21 is an inhibitor of cyclin-dependent kinase and acts to prevent protein retinoblastoma (pRb) phosphorylation by inhibiting activation of cyclin E/cdk2 complexes that are required for Rb phosphorylation. Expression of p21 is regulated by a number of signaling molecules, including p53 and K-ras.
p21 in cancer: intricate networks and multiple activities
WEBThe cyclin-dependent kinase inhibitor p21 (also known as p21 WAF1/Cip1) promotes cell cycle arrest in response to many stimuli. It is well positioned to function as both a sensor and an effector of multiple anti-proliferative signals.
p21: A Two-Faced Genome Guardian: Trends in Molecular …
WEBMar 6, 2017 · p21 is a two-faced regulator depending on cell type, cellular localization, p53 status, and the type and level of genotoxic stress. It can acquire either oncosuppressive or oncopromoting properties depending on whether it is in a p53-proficient or p53-deficient environment, respectively.
p21 | SpringerLink
WEBJan 1, 2017 · The p21 gene is a transcriptional target for multiple proliferation-inhibitory signaling cascades, including p53 (which can be activated in response to DNA damage), TGF (transforming growth factor beta), TNF (tumor necrosis factor alpha), IFN (interferon gamma), or APC (adenomatosis polyposis coli). p21 binds to the DNA polymerase …