Efficient biosynthesis of nucleoside cytokinin angustmycin A containing ...
网页2021年11月17日 · Nature Communications - Angustmycin A is a nucleoside antibiotic having anti-mycobacterial and cytokinin activities. Here, the authors report the whole pathway leading to angustmycin A...
Cytokinins: Current Biology - Cell Press
网页2023年1月9日 · Cytokinin degradation is performed by the CYTOKININ OXIDASE/DEHYDROGENASE (CKX) proteins that remove the N 6-isoprene side chain. (B) Three different cytokinin transporters have been identified: the equilibrative nucleoside transporters (ENTs), the purine permeases (PUPs), and the G subfamily ATP-binding cassette (ABCG) transporters.
网页In the present paper, we address the mechanism for the bio-synthesis of the angustmycin family of nucleotide antibiotics. We demonstrate a six-enzyme pathway for the biosynthesis of 1, which ...
Efficient biosynthesis of nucleoside cytokinin angustmycin A containing ...
网页2021年11月17日 · Angustmycin A is a nucleoside antibiotic having anti-mycobacterial and cytokinin activities. Here, the authors report the whole pathway leading to angustmycin A biosynthesis in Streptomyces and achieve the heterologous …
含有不寻常糖系统的核苷细胞分裂素安格斯霉素 A 的高效生物合 …
网页Angusmycin A 具有抗分枝杆菌和细胞分裂素活性，并包含一个有趣的结构，其中具有 C5'-C6' 脱水的不寻常糖通过 N- 糖苷键连接到腺嘌呤。. 然而，这种分子生物合成背后的逻辑长期以来一直模糊不清。. 在这里，我们通过完全破译其途径来解决安格斯霉素 A 的生物 ...
Biochemical and Structural Aspects of Cytokinin Biosynthesis and ...
网页2021年6月16日 · An overview of cytokinin (CK) metabolism as identified in plants and bacteria. (a) De novo CK biosynthesis pathway; (b) tRNA-dependent CK biosynthesis pathway. The key enzymes involved in CK biosynthesis and activation are isopentenyl transferase (IPT), cytochrome P450 monooxygenase (CYP450), CK phosphoribohydrolase “Lonely guy” (LOG), tRNA ...
Biosynthesis of the nucleoside antibiotic angustmycins: …
网页2021年8月17日 · The nucleoside antibiotic angustmycin, produced by some Streptomyces strains, is composed of adenine and C 6 sugar and shows antibiotic and antitumor activities. In this study, we propose a ...
Cytokinins, the Cinderella of plant growth regulators
网页Cytokinins (CKs) are a complex group of compounds. The complexity of CKs is not just present at the level of chemical structures, but as a family of compounds. CKs occur in plants as nucleotides, nucleosides (ribosides) that are produced during de novo biosynthesis, free bases, and conjugates that are in stored/inactivated forms.
Cytokinin Nucleosides - Natural Compounds with a Unique
网页Cytokinins are N6-substituted adenines and represent an important group of phytohormones with diverse biochemical functions in plants, stimulating cell division and plant growth. The main structural feature of cytokinin nucleosides is the presence of a hydrophobic hydrocarbon moiety at the N6-position of adenosine.
Efficient biosynthesis of nucleoside cytokinin angustmycin A containing ...
网页2021年11月17日 · Angustmycin A has anti-mycobacterial and cytokinin activities, and contains an intriguing structure in which an unusual sugar with C5'-C6' dehydration is linked to adenine via an N-glycosidic bond. However, the logic underlying the biosynthesis of this molecule has long remained obscure. Here, we ad …