Classical and Novel GH Receptor Signaling Pathways - PMC
网页2020年12月12日 · In this review, I summarize historical and recent features of the classical pathways activated by growth hormone (GH) through the cell surface GH receptor (GHR). GHR is a cytokine receptor superfamily member that signals by activating the non-receptor tyrosine kinase, JAK2, and members of the Src family kinases.
The Growth Hormone Receptor: Mechanism of Receptor …
网页2018年2月13日 · The growth hormone receptor (GHR), although most well known for regulating growth, has many other important biological functions including regulating metabolism and controlling physiological processes related to the hepatobiliary, cardiovascular, renal, gastrointestinal, and reproductive systems.
Growth hormone receptor - Wikipedia
网页Growth hormone receptor (GHR) is a transmembrane protein consisting of 620 amino acids. The receptor is part of the Type I cytokine receptor family of receptors. GHR exists in two forms as a full length membrane-bound receptor and as a …
Targeting growth hormone function: strategies and therapeutic ...
网页2019年2月8日 · Human growth hormone (GH) is a peptide hormone that is secreted from the anterior pituitary. It has a central function of regulating postnatal growth and metabolism and...
生长激素受体 - 维基百科，自由的百科全书
网页生长激素受体（英語： Growth hormone receptor)是一种由人类基因GHR 编码的蛋白质 [1] ，GHR的直系同源物 [2] 广泛存在于各种哺乳动物中。 此基因编码的蛋白是结合 生长激素 的跨膜受体。
Growth hormone receptor disrupts glucose homeostasis via …
网页2021年7月13日 · Growth hormone receptor (GHR) deficiency has long been known to improved insulin sensitivity. However, whether hepatic GHR overexpression or activation is a cause of insulin resistance is still unknown. The aim of this study was to identify the new role of GHR in systemic insulin resistance and explore the underlying mechanism.
Regulation of human growth hormone receptor expression by …
网页Human GH binds to its receptor (GHR) on target cells and activates multiple intracellular pathways, leading to changes in gene expression, differentiation, and metabolism. GHR deficiency is associated with growth and metabolic disorders whereas increased GHR expression has been reported in certain c ….
Growth hormone receptor: structure and signal transduction
网页The growth hormone receptor (GHR) belongs to the superfamily of transmembrane proteins that includes the prolactin receptor and a number of cytokine receptors. Two forms exist for the GHR: the full-length membrane-bound human receptor is a protein of 620 amino acids with a single transmembrane regio …
Model for growth hormone receptor activation based on subunit …
网页2005年8月21日 · Growth hormone is believed to activate the growth hormone receptor (GHR) by dimerizing two identical receptor subunits, leading to activation of JAK2 kinase associated with the cytoplasmic...
GH and GHR signaling in human disease - PubMed
网页Human Growth Hormone. Along with its inherent properties in growth promotion, cell division and regeneration, growth hormone (GH) exerts a variety of miscellaneous and widespread actions on the human body after binding to its receptor (GHR). Indeed, GH influences the metabolism of carbohydrates, lipids and proteins; shap ….
跳至内容