A CRISPR-Cas9 screen identifies EXO1 as a formaldehyde
网页2023年1月24日 · To identify genes involved in response to formaldehyde, we performed a pangenomic CRISPR-Cas9 screen in h-TeRT-immortalized RPE-1 cells (RPE-1), a well-characterized normal cell line commonly...
Mammals divert endogenous genotoxic formaldehyde into one
网页2017年8月16日 · The folate-driven one-carbon (1C) cycle is a fundamental metabolic hub in cells that enables the synthesis of nucleotides and amino acids and epigenetic modifications. This cycle might also...
formaldehyde catabolic process | CTD
网页The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde. Ontology Biological Process
formaldehyde catabolic process Gene Ontology Term …
网页The Gene Ontology (GO) project is a collaborative effort to address the need for consistent descriptions of gene products across databases. You can use this browser to view terms, definitions, and term relationships in a hierarchical display. Links to summary annotated gene data at MGI are provided in Term Detail reports.
Formaldehyde metabolism and its impact on human health
网页2018年6月1日 · Formaldehyde catabolism initiates with the spontaneous reaction between the aldehyde and glutathione to form S-hydroxymethylglutathione (HMGSH). The enzyme ADH5 oxidizes HMGSH to S -formylglutathione (FGSH) using NAD(P) + as a cofactor [31].
Perspectives on formaldehyde dysregulation: Mitochondrial DNA …
网页Metabolic homeostasis of formaldehyde is preserved by mechanisms that prevent formaldehyde dysregulation through controlled formaldehyde generation and degradation processes. Formaldehyde excess has detrimental effects on genome stability, posing a threat to normal cellular functions.
formaldehyde catabolic process - Semantic Scholar
网页formaldehyde catabolic process. Known as: formaldehyde breakdown, methanal catabolism, methanal catabolic process. Expand. The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the …
formaldehyde catabolic process | SGD - Saccharomyces Genome …
网页Biological Process Description The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde. Synonyms
Mammals divert endogenous genotoxic formaldehyde into …
网页2017年8月31日 · The folate-driven one-carbon (1C) cycle is a fundamental metabolic hub in cells that enables the synthesis of nucleotides and amino acids and epigenetic modifications. This cycle might also release formaldehyde, a potent protein and DNA crosslinking agent that organisms produce in substantial quanti ….
Formaldehyde exposure induces regulatory T cell-mediated ...
网页2020年10月12日 · In this study, we investigated the effects of Formaldehyde (FA) exposure on splenic immune responses wherein helper T cells become activated and differentiate into effector T and regulatory T...
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