PTPRC - Wikipedia
网页The protein product of this gene, best known as CD45, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
Protein tyrosine phosphatase receptor type C (PTPRC or CD45)
网页2021年5月26日 — The leucocyte common antigen, protein tyrosine phosphatase receptor type C (PTPRC), also known as CD45, is a transmembrane glycoprotein, expressed on almost all haematopoietic cells except for mature erythrocytes, and is an essential regulator of T and B cell antigen receptor-mediated activation.
The role of CD45 and CD45-associated molecules in T cell activation
网页CD45 (lymphocyte common antigen) is a receptor-linked protein tyrosine phosphatase that is expressed on all leucocytes, and which plays a crucial role in the function of these cells.
CD45 functions as a signaling gatekeeper in T cells - Science
网页2019年10月22日 — CD45 activates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts.
CD45 in human physiology and clinical medicine - ScienceDirect
网页2018年4月1日 — CD45 is an evolutionary highly conserved receptor protein tyrosine phosphatase exclusively expressed on all nucleated cells of the hematopoietic system. It is characterized by the expression of several isoforms, specific to a certain cell type and the developmental or activation status of the cell.
CD45: new jobs for an old acquaintance | Nature Immunology
网页Identified as the first and prototypic transmembrane protein tyrosine phosphatase (PTPase), CD45 has been extensively studied for over two decades and is thought to be important for...
CD45 pre-exclusion from the tips of T cell microvilli prior to …
网页2021年6月23日 — The tyrosine phosphatase CD45 is a major gatekeeper for restraining T cell activation. Its exclusion from the immunological synapse (IS) is crucial for T cell receptor (TCR) signal...
CD45: a critical regulator in immune cells to predict severe and …
网页2020年10月10日 — CD45 is a transmembrane phosphatase that functions in T cell activation and signaling. Multiple CD45 isoforms are simultaneously expressed on T cells due to alternative splicing of three exons that correspond to extracellular domains A, B, and C or the exclusion of all three (CD45RO).
Differential Regulation of CD45 Expression on Granulocytes, …
网页2022年7月20日 — CD45 (common leucocyte antigen) is a transmembrane glycoprotein with a molecular weight of 180–220 kDa expressed on all leucocytes and constitutes about 10% of cell surface antigens [1, 2, 3]. CD45 is highly conserved and exists not only in mammals, but also in chicken, sharks, and mosquitos [4].
CD45 is a JAK phosphatase and negatively regulates cytokine …
网页2001年1月18日 — The transmembrane PTPase CD45 is a key regulator of antigen receptor signalling in T and B cells2,3. Src-family kinases have been identified as primary molecular targets for CD45 (ref. 4).
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