Bilirubin glucuronide - Wikipedia
网页Bilirubin glucuronide is a water-soluble reaction intermediate over the process of conjugation of indirect bilirubin. [1] Bilirubin glucuronide itself belongs to the category of conjugated bilirubin along with bilirubin di-glucuronide. [2] However, only the latter one is primarily excreted into the bile in the normal setting. [2] [3] [4] [5] [1]
Physiology, Bilirubin - StatPearls - NCBI Bookshelf
网页2022年9月12日 · The enzyme esterifies 2 glucuronide moieties to bilirubin's propionic acid side chains. Under normal conditions, bilirubin diglucuronide is the predominant molecule synthesized. However, if the conjugation system is overwhelmed under conditions of excessive bilirubin synthesis, most bilirubin may be conjugated as bilirubin monoglucuronide.
Glucuronidated bilirubin: Significantly increased in hepatic ...
网页Bilirubin. Bilirubin is produced by the breakdown of hemoglobin in senescent erythrocytes by macrophages and carried by albumin from blood circulation to the liver for removal in normal physiology. Glucuronic acid modification of bilirubin by UDP-glucuronyltransferase in the liver is the key event for its subs ….
Bilirubin Glucuronide - an overview | ScienceDirect Topics
网页Bilirubin (Table 7-1) is the end product of heme catabolism. Bilirubin gives bile its characteristic color and accounts for the yellow discoloration observed in jaundice patients. More than 80% of bilirubin is derived from the breakdown of red blood cells in the mononuclear phagocyte (reticuloendothelial) system.
Bilirubin Glucuronide - an overview | ScienceDirect Topics
网页Bilirubin Glucuronide is a water-soluble form of bilirubin that is produced in the liver through the modification of bilirubin by UDP-glucuronyltransferase. It plays a key role in the elimination of bilirubin from the human body.
Measurement and clinical usefulness of bilirubin in liver disease
网页2021年7月9日 · Bilirubin is an orange-yellow pigment of bile that results from the degradation of various heme-containing proteins, especially from hemoglobin catabolism. Heme is broken down into biliverdin, which is converted into unconjugated or indirect bilirubin (UCB). UCB is water-insoluble and enters circulation bound to albumin.
All you need to know about bilirubin (and liver function)
网页2021年1月26日 · In the liver, unconjugated bilirubin binds to glucuronide by the enzyme uridine 5’-diphospho-glucuronosyltransferase (UDP). The product is conjugated bilirubin, which can be excreted in bile. In the intestines, bacterial enzymes hydrolyze conjugated bilirubin to release free, unconjugated bilirubin, which is reduced to urobilinogen.
Transport mechanism of human bilirubin transporter ABCC2 …
网页2024年2月5日 · In hepatocytes, the highly hydrophobic bilirubin molecule is subject to conjugation with two glucuronide groups by the UDP-glucuronosyltransferase, producing the hydrophilic conjugated form 2,...
Bilirubin Glucuronidation Revisited: Proper Assay Conditions …
网页2010年4月7日 · Bilirubin is a toxic waste product, formed from heme degradation. In humans, approximately 250 to 400 mg of bilirubin are produced each day (Brierley and Burchell, 1993). Glucuronidation of bilirubin, catalyzed primarily by UGT1A1, is an obligatory step for bilirubin elimination and takes place in the liver and intestine (Kadakol et …
Simultaneous determination of bilirubin and its glucuronides in …
网页In the present study, we developed a simple and robust HPLC method for simultaneous determination of unconjugated bilirubin (UCB) and its multiple glucuronides, i.e. bilirubin monoglucuronides (BMGs, including BMG1 and BMG2 isomers) and diglucuronide (BDG) in rat liver microsomes (RLM), human liver microsomes …