α-Glucosidase - Wikipedia
网页α-Glucosidase (EC 3.2.1.20, (systematic name α-D-glucoside glucohydrolase) is a glucosidase located in the brush border of the small intestine that acts upon α (1→4) bonds: [1][2][3][4][5][6] This is in contrast to EC 3.2.1.21 β-glucosidase.
Alpha Glucosidase Inhibitors - StatPearls - NCBI Bookshelf
网页2024年2月28日 · Alpha-glucosidase inhibitors (AGIs) are therapeutic agents in managing type 2 diabetes. Acarbose and miglitol are FDA-approved and are prominent members of this drug class. AGIs are also prescribed for patients with impaired glucose tolerance, demonstrating their utility in delaying the onset of diabetes in this cohort.
Alpha-Glucosidase - an overview | ScienceDirect Topics
网页Alpha-glucosidase is an enzyme in the upper gastrointestinal tract that converts polysaccharides of complex carbohydrates into monosaccharides in a dose-dependent manner. Its inhibition through drugs such as acarbose, miglitol and voglibose slows glucose absorption, culminating in a slower rise in postprandial blood glucose concentrations. 128
Alpha-Glucosidase - an overview | ScienceDirect Topics
网页Alpha-glucosidase is an intestinal enzyme that releases glucose during the digestion of the ingested carbohydrates. It is a membrane-bound enzyme abundant in the brush border of small intestines, which hydrolyzes oligosaccharides, trisaccharides, and disaccharides to glucose and other monosaccharides in the intestinal lumen.
What Are Alpha-Glucosidase Inhibitors for Diabetes? - WebMD
网页2023年5月21日 · Alpha-glucosidase inhibitors are pills that treat type 2 diabetes. There are two medications in this group, or class, of drugs: acarbose (Precose) and miglitol (Glyset). They help keep the amount...
Alpha-glucosidase inhibitors for treatment of diabetes mellitus
网页2024年1月4日 · Alpha-glucosidase inhibitors lower blood glucose by modifying the intestinal absorption of carbohydrates. The glycemic efficacy, adverse effects, and dosing of alpha-glucosidase inhibitors will be discussed here.
Structure of human lysosomal acid α-glucosidase–a guide for …
网页2017年10月24日 · Pompe disease is caused by mutations in lysosomal acid α-glucosidase (GAA) and patients are being treated with recombinant human α-glucosidase (rhGAA). Here the authors present the crystal ...
Alpha Glucosidase - an overview | ScienceDirect Topics
网页1999年5月4日 · Alpha-glucosidase is an enzyme that is inhibited by certain medications to prevent the breakdown of complex carbohydrates into glucose in the small intestine, leading to reduced glucose absorption. AI generated definition based on: Drug-Induced Liver Disease (Third Edition), 2013
α-Glucosidases and α-1,4-glucan lyases: structures, functions, and ...
网页2016年4月30日 · α-Glucosidase (AGase; EC 3.2.1.20) is a typical exohydrolase that reacts with the α-glucosidic linkage of the non-reducing terminal of substrates and releases α-glucose [1, 2]. Under high substrate concentrations, the enzyme also catalyzes transglucosylation, synthesizing oligosaccharides (Fig. 1 a).
alpha-Glucosidases - PubMed
网页This review highlights the main properties of mammalian, plant, and microbial alpha-glucosidases. Special attention is given to the classification of these enzymes, possible catalytic mechanisms, their tertiary structure, and the structure of major inhibitors.
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