Ubiquitin - Wikipedia
网页Ubiquitin is a small protein that exists in all eukaryotic cells. It performs its myriad functions through conjugation to a large range of target proteins. A variety of different modifications can occur. The ubiquitin protein itself consists of 76 amino acids and has a molecular mass of about 8.6 kDa.
The ubiquitin system: from cell signalling to disease biology …
网页2021年1月14日 · Ubiquitin modifications control a plethora of vital cellular processes through proteolytic and nonproteolytic mechanisms, including proteasomal degradation and proteostasis, selective autophagy...
Ubiquitin - an overview | ScienceDirect Topics
网页Ubiquitin is a small polypeptide that functions as a molecular tag to mark proteins for degradation or to participate in various cellular processes such as DNA repair and protein localization. It is attached to proteins through a multistep enzymatic process called ubiquitination, involving enzymes known as E1, E2, and E3.
Ubiquitin: structures, functions, mechanisms - PubMed
网页2004年11月29日 · Ubiquitin is the founding member of a family of structurally conserved proteins that regulate a host of processes in eukaryotic cells. Ubiquitin and its relatives carry out their functions through covalent attachment to other cellular proteins, thereby changing the stability, localization, or activi ….
Ubiquitin: structures, functions, mechanisms - ScienceDirect
网页2004年11月29日 · Ubiquitin is the founding member of a family of structurally conserved proteins that regulate a host of processes in eukaryotic cells. Ubiquitin and its relatives carry out their functions through covalent attachment to other cellular proteins, thereby changing the stability, localization, or activity of the target protein.
Biochemistry, Ubiquitination - StatPearls - NCBI Bookshelf
网页2023年3月16日 · Ubiquitination is a three-step process involving three enzymes: ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), and ubiquitin-protein ligase (E3). E1 activates ubiquitin in an ATP-dependent manner, enabling its transfer onto the ubiquitin carrier enzyme, E2.
Ubiquitin modifications | Cell Research - Nature
网页2016年3月25日 · We here provide an overview of the various ubiquitin modifications present in cells, and highlight recent progress on ubiquitin chain biology.
Ubiquitin: Structure and Function - IntechOpen
网页2024年2月28日 · Ubiquitin is a small (8.6 kDa) protein that is found ‘ubiquitously’ in eukaryotic organisms and functions as a regulator of numerous cellular processes. It is a multifaceted post-translational modifier of other proteins involved in …
Ubiquitin-binding domains — from structures to functions
网页Ubiquitin-binding domains (UBDs) are modular elements that bind non-covalently to the protein modifier ubiquitin. Specific ubiquitin–UBD interactions are crucial for the regulation of...
Ubiquitin System - PMC - National Center for Biotechnology …
网页2018年4月4日 · Ever since the discovery of ubiquitin in 1975 , extensive research studies have shown that the ubiquitin system is essential for maintaining homeostasis of the body by controlling a wide range of cellular functions.