Indolamines - Wikipedia
网页Indolamines are a family of neurotransmitters that share a common molecular structure (namely, indolamine). Indolamines are a classification of monoamine neurotransmitter, along with catecholamines and ethylamine derivatives.
Indoleamine 2,3-dioxygenase (IDO): Biology and Target in Cancer ...
网页Indoleamine 2,3-dioxygenase (IDO) is a heme-containing oxidoreductase that catalyzes the initial and rate-limiting step in the breakdown of non-dietary tryptophan. The biology and immunomodulatory role for IDO is discussed in this review with a focus on its interaction with immune cells and its pote ….
IDO: more than an enzyme - Nature Immunology
网页2011年8月18日 · Indoleamine 2,3-dioxygenase (IDO) is an enzyme that catalyzes degradation of the essential amino acid tryptophan in many types of cells, including dendritic cells (DCs), and...
Structural insights into substrate and inhibitor binding sites
网页2017年11月22日 · Human indoleamine 2,3-dioxygenase 1 (hIDO1) is an immunotherapeutic target for cancer therapy. Here, the authors present the substrate-, inhibitor- and effector-bound hIDO1 crystal structures ...
Indoleamine 2,3‐dioxygenase 1 (IDO1): an up‐to‐date overview of …
网页2021年6月30日 · Indoleamine 2,3‐dioxygenase 1 (IDO1) catalyzes the initial rate‐limiting step in the degradation of the essential amino acid tryptophan along the kynurenine pathway. When discovered more than 50 years ago, IDO1 was thought to be an effector molecule capable of mediating a survival strategy based on …
The Role of Indoleamine 2, 3-Dioxygenase in Immune …
网页2015年9月10日 · Indoleamine 2, 3-dioxygenase (IDO) is the first and rate limiting catabolic enzyme in the degradation pathway of the essential amino acid tryptophan. By cleaving the aromatic indole ring of tryptophan, IDO initiates the production of a variety of tryptophan degradation products called “kynurenines” that are known to exert important immuno ...
Indoleamine 2,3-Dioxygenase 1: A Promising Therapeutic Target …
网页2021年12月23日 · Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the first and rate-limiting enzyme of the essential amino acid Trp catabolism and degrades Trp along a pathway known as the Kyn pathway. In this cascade of enzymatic reactions, several biologically active metabolites are produced, such as …
Indoleamine 2,3‐dioxygenase 1 (IDO1): an up‐to‐date overview …
网页2021年6月19日 · Indoleamine 2,3-dioxygenase 1 (IDO1) is a cytosolic, monomeric, heme-containing enzyme that catalyzes the initial rate-limiting step in the degradation of the essential amino acid l-tryptophan (l-Trp) along a pathway known …
Frontiers | The Role of Indoleamine-2,3-Dioxygenase in Cancer ...
网页2018年1月30日 · Indolamine-2,3-dioxygenase 1 is a cytosolic enzyme with a heme (Fe 2+) prosthetic group that catalyzes the first and rate-limiting step of tryptophan (Trp) catabolism (Figure 1 A).
Discovery and characterization of natural products as novel indoleamine …
网页2019年6月13日 · Indoleamine 2,3-dioxygenase 1 (IDO1) is emerging as a promising therapeutic target for the treatment of malignant tumors characterized by dysregulated tryptophan metabolism. However, the...