Stem cells and healthy aging | Science - AAAS
网页2015年12月4日 · Research into stem cells and aging aims to understand how stem cells maintain tissue health, what mechanisms ultimately lead to decline in stem cell function with age, and how the regenerative capacity of somatic stem cells can be enhanced to promote healthy aging. Here, we explore the effects of aging on stem cells in different tissues.
Stem cells and healthy aging - PubMed
网页2015年12月4日 · Research into stem cells and aging aims to understand how stem cells maintain tissue health, what mechanisms ultimately lead to decline in stem cell function with age, and how the regenerative capacity of somatic stem cells can be enhanced to promote healthy aging. Here, we explore the effects of ag ….
Rejuvenating Strategies of Tissue-specific Stem Cells for Healthy Aging
网页2019年8月1日 · As stem cells are the longest-living cells within an organism, stem cell aging is highly relevant as a driver of organismal aging, health and longevity. In this review, we demonstrate that by targeting aging mechanisms, the aging associated phenotypes and functions of tissue-specific stem cells can be reversed.
Ageing and rejuvenation of tissue stem cells and their niches
网页2022年7月20日 · Evidence for the contribution of enhanced stem cell function to tissue health and lifespan is so far most compelling in cases when endogenous, old cells are replaced by young cells or are...
Stem cells to reverse aging - PMC - National Center for …
网页2022年4月4日 · These cells play a key role in tissue regeneration and repair. ASCs differentiate into adipocytes, osteoblasts, chondrocytes, hepatocytes, nerve cells, and other downstream SCs to replace or repair aging damaged cells and thereby achieve a balance between cell regeneration and aging.
Intestinal stem cells: guardians of homeostasis in health and aging ...
网页2024年3月1日 · Central to maintaining a healthy epithelium are intestinal stem cells (ISCs), which are essential for replenishing the intestinal epithelium throughout an individual’s lifespan. Recent...
Optimizing health-span: advances in stem cell medicine and …
网页2023年10月10日 · The eight functional “R”s of “R2T” stem cell medicine are self-Renewal, Reprogramming, Regeneration, Rejuvenation, Repair, Reversal, Rehabilitation, and Remodeling of animal use. To achieve the optimal human health span, thriving research programs on stem cell medicine targeting landmark clinical …
网页Research into stem cells and aging aims to understand how stem cells maintain tissue health, what mechanisms ultimately lead to decline in stem cell function with age, and how the regenerative capacity of somatic stem cells can be enhanced to promote healthy aging. Here, we explore the effects of aging on stem cells in different tissues.
A stem cell aging framework, from mechanisms to interventions - Cell …
网页2022年10月18日 · In this review, we elucidate aging-related features across different somatic stem cell types, with a specific focus on epigenetic changes, loss of protein homeostasis, and systemic influencing factors, including chronic inflammation, circadian rhythm dysregulation, and metabolic disorder.
Stem cell aging: mechanisms, regulators and therapeutic ... - Nature
网页2014年8月6日 · Aging tissues experience a progressive decline in homeostatic and regenerative capacities, which has been attributed to degenerative changes in tissue-specific stem cells, stem cell niches...
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