NRF2, a Transcription Factor for Stress Response and Beyond
网页2020年7月6日 · Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative stress response and drug detoxification.
An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation
网页2020年11月23日 · Recent studies showed a connection between the Nrf2/antioxidant response element (ARE) system and the expression of inflammatory mediators, NF-κB pathway and macrophage metabolism. This suggests a new strategy for designing chemical agents as modulators of Nrf2 dependent pathways to target the immune response.
Nrf2 and Oxidative Stress: A General Overview of Mechanisms and ...
网页2022年11月27日 · Nuclear factor erythroid 2-related factor 2 (Nrf2) is the transcriptional master regulator of cellular responses against oxidative stress.
Nrf2, the Master Regulator of Anti-Oxidative Responses
网页2017年12月20日 · Stabilized following oxidative stress, Nrf2 induces the expression of antioxidants as well as cytoprotective genes, which provoke an anti-inflammatory expression profile, and is crucial for the initiation of healing.
Nrf2: Redox and Metabolic Regulator of Stem Cell State and …
网页2019年11月1日 · Nuclear factor erythroid 2-related factor 2 (Nrf2) is ubiquitously expressed in most eukaryotic cells and functions to induce a broad range of cellular defenses against exogenous and endogenous stresses, including oxidants, xenobiotics, and excessive nutrient/metabolite supply.
Advances and challenges in therapeutic targeting of NRF2 - Cell …
网页2023年1月9日 · The inducible transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) regulates the expression of several hundred genes encoding proteins with antioxidant, anti-inflammatory, drug metabolising, and other homeostatic functions.
Nrf2 plays a critical role in the metabolic response during ... - Nature
网页2021年12月9日 · These metabolic and physiological changes were largely driven by Nrf2 (NF-E2-related factor-2), ultimately providing a mechanistic target for altering lipid metabolism on Earth and the...
Nrf2 suppresses macrophage inflammatory response by blocking ...
网页2016年5月23日 · This study identifies Nrf2 as the upstream regulator of cytokine production and establishes a molecular basis for an Nrf2-mediated anti-inflammation approach.
The antioxidative stress regulator Nrf2 potentiates radioresistance …
网页2022年4月12日 · Nuclear factor erythroid 2-related factor 2 (Nrf2), which regulates the expression of critical antioxidant proteins, was recently demonstrated to play a key role in cancer...
Regulation of innate immunity by Nrf2 - PubMed
网页The transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) has been mainly investigated as a regulator of redox homeostasis. However, research over the past years has implicated Nrf2 as an important regulator of innate immunity.
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