Deamination - Wikipedia
网页Deamination is the removal of an amino group from a molecule. [1] Enzymes that catalyse this reaction are called deaminases. In the human body, deamination takes place primarily in the liver; however, it can also occur in the kidney.
ada（腺苷脱氨酶）_百度百科
网页腺苷脱氨酶（Adenosine deaminase）是一种参与嘌呤代谢作用的酶。 它是用作拆解食物组织中的核酸中的腺苷。 在人体中，它主要参与了免疫细胞的制造；若该酶突变，会造成T细胞、B细胞、自然杀伤细胞皆无法表现的严重复合型免疫缺乏症(SCID)
腺苷脫氨酶 - 维基百科，自由的百科全书
网页腺苷脫氨酶 （英語： Adenosine deaminase）的是一種參與 嘌呤代謝作用 的 酶。 它是用作拆解食物組織中的 核酸 中的 腺苷。 在人體中，它主要參與了免疫細胞的製造。 若該酶突變，會造成 T細胞 、 B細胞 及 自然殺手細胞 皆無法表現的 嚴重複合型免疫缺乏症 (SCID)。 反應. 腺苷脫氨酶對 腺苷 進行不可逆轉的 脫氨 作用，轉化腺苷為相關的 核苷肌苷，移除 氨基酸組。 病理學. 腺苷脫氨酶的 突變 基因使之不容易被表達，這是一些 嚴重複合型免疫缺 …
Adenosine deaminase - Wikipedia
网页Adenosine deaminase (also known as adenosine aminohydrolase, or ADA) is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues. Its primary function in humans is the development and maintenance of the immune system. [5]
Deaminase - an overview | ScienceDirect Topics
网页A deaminase is an enzyme that acts on RNA molecules by converting adenosine (A) to inosine (I) in double-stranded RNA. It contains specific domains for binding to RNA and catalyzing the deamination process.
Discovery of deaminase functions by structure-based protein …
网页2023年7月20日 · Deaminase-like proteins catalyze the deamination of nucleotides and bases in nucleic acids. They play important roles in defense, mutation, nucleic acid metabolism, and in other biological processes 10, 11, 12, 13 and have been recently exploited for use in programmable DNA and RNA base editors, 14, 15, 16 a class of precise genome editing ...
Discovery of deaminase functions by structure-based protein
网页2023年7月20日 · We engineered the smallest single-strand-specific cytidine deaminase, enabling efficient cytosine base editor (CBE) to be packaged into a single adeno-associated virus (AAV). Importantly, we profiled a deaminase from this clade that edits robustly in soybean plants, which previously was inaccessible to CBEs.
Deaminase deluge yields new opportunities for ... - Cell Press
网页2024年3月7日 · In this issue of Molecular Cell, Vaisvila et al.1 report a tour de force functional characterization of a large and highly diverse set of polynucleotide cytosine deaminase (PCD) enzymes, which is already propelling new biotechnology applications.
Deaminase - an overview | ScienceDirect Topics
网页Deamination reactions are the major types of base modification in mammals. Conversion of cytosine (C) or adenosine (A) to uracyl (U) or inosin (I), respectively, might change coding potential of mRNA (s) and result in the synthesis of protein isoform (s) not predictable from genomic DNA sequence.
Structure-Guided Discovery of New Deaminase Enzymes
网页2013年9月9日 · A substantial challenge for genomic enzymology is the reliable annotation for proteins of unknown function. Described here is an interrogation of uncharacterized enzymes from the amidohydrolase superfamily using a structure-guided approach that integrates bioinformatics, computational biology and molecular enzymology.