Nature | 丁璟珒与邵峰团队破解GSDMB可变剪接调控细胞焦亡活性 …
2023年3月31日 — 北京生命科学研究所/清华大学生物医学交叉研究院邵峰团队在2020年发现，细胞毒性淋巴细胞分泌的颗粒酶A (GZMA) 特异地切割和活化靶细胞内gasdermin家族的成 …
Structural mechanisms for regulation of GSDMB pore-forming …
2023年3月29日 — The structure of full-length GSDMB suggests stronger autoinhibition than in other gasdermins 9, 10. GSDMB has multiple splicing isoforms that are equally targeted by IpaH7.8 but exhibit ...
GSDMB is increased in IBD and regulates epithelial …
2022年1月20日 — Gasdermin B (GSDMB) is currently the least studied, and while its association with genetic susceptibility to chronic mucosal inflammatory disorders is well established, little is known about its functional relevance during active disease states.
Science | 邵峰：GSDMB被颗粒酶激活进而诱导靶细胞发生焦亡
2020年4月20日 — 该研究发现在细胞毒性淋巴细胞杀伤靶细胞的过程中，细胞毒性淋巴细胞来源的Granzyme A蛋白能够特异地高效激活Gasdermin B (GSDMB) 蛋白，从而导致靶细胞发生细胞焦亡，该分子机制能够.
GSDMB is increased in IBD and regulates epithelial …
2022年1月11日 — GSDMB is increased in IBD versus healthy patients and localizes to the gut epithelium. •. GSDMB promotes epithelial restitution and repair independent of pyroptosis. •. Carriage of IBD-associated mutant GSDMB confers dysregulated epithelial function. •. PDGF-A-mediated FAK phosphorylation is regulated by GSDMB. Summary.
Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases …
Crystal structures of caspase-11 alone or in complex with GSDMD reveal an exosite in the autoprocessed caspase-11 that mediates high-affinity binding to GSDMD. Structures of caspase-4-GSDMD and caspase-1-GSDMD complexes highlight the conservation of this unprecedented substrate-targeting mechanism for caspases.
GSDMB在细胞焦亡和恶性肿瘤中的研究进展 - 国际遗传学杂志
GSDMB (Gasdermin B)属于GSDM蛋白家族，可通过不同的分子内结构域作用机制来调节其脂质结合和成孔活性，参与细胞焦亡。. 细胞焦亡是一种调控细胞死亡的促炎症形式，其本质是一种级联放大的炎症反应，常参与免疫防御，并在肿瘤的发生发展中发挥双重作用 ...
GSDMB 在 IBD 中增加，并独立于焦亡调节上皮恢复/修复,Cell - X …
Gasdermin 是一个结构相关的蛋白质家族，最初描述其在细胞焦亡中的作用。. Gasdermin B (GSDMB) 目前研究最少，虽然其与慢性粘膜炎症性疾病遗传易感性的关联已得到充分证实，但对其在活动性疾病状态下的功能相关性知之甚少。. 在此，我们报告了炎症性肠病中 GSDMB ...
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger ...
Zhou et al. show that granzyme A cleaves and activates gasdermin B (GSDMB), a central player in the highly inflammatory cell death process known as pyroptosis (see the Perspective by Nicolai and Raulet). GSDMB expression was highly expressed in …
Cytotoxic CD8 + T cells promote granzyme B-dependent adverse …
2021年3月5日 — Cytotoxicity of CD8 + T cells was abolished in case of Granzyme B deficiency (Fig. 4K). We also hypothesized that the effect of CD8 T lymphocytes expressing Granzyme B exceeds a simple cytotoxic ...