A new therapeutic agent discovered and developed at The Ohio State University will soon be used for cancer treatment at the patient's bedside as part of a clinical trial.

F2G submitted its initial approval application with data from the first 100 patients enrolled in a phase 2b study of the drug ...

Marshall, J. R., and Walker, J., J. Chem. Soc., 1004 (1951). Brown, D. J., Hoerger, E., and Mason, S. F., J. Chem. Soc., 211 (1955). Wang, S. Y., J. Amer. Chem. Soc ...

In addition, the drug inhibits the enzyme DHODH, thereby blocking the production of pyrimidines, which cells rely on primarily for RNA synthesis. It is particularly effective in highly activated ...

THREE pyrimidines have been found to occur in Nature as constituents of the nucleoproteins, the chief protein material of the cell nucleus. These pyrimidines are: uracil, thymine and cytosine.

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SMC complexes, such as condensin or cohesin, organize chromatin throughout the cell cycle by a process known as loop extrusion. SMC complexes reel in DNA, extruding and progressively growing DNA loops ...

In all characterized RNRs, the binding of effector dATP alters the active site to select for pyrimidines over purines, whereas effectors dGTP and TTP select for substrates ADP and GDP, respectively.