Patients with COPD taking ivacaftor for 12 weeks showed no significant changes in CFTR activity or mucociliary clearance, and lung function did not improve. Ivacaftor was safe and well tolerated but ...
Other commonly associated problems are the need for medications which suppress an already compromised cough reflex, and impairment of the mucociliary apparatus by cytotoxic drugs, and/or radiation.
Mucociliary dysfunction, chronic infections with advancing immunosenescence and pulmonary emphysema as seen in COPD may be just as relevant to ACOS. Possible drug targets include receptors of the ...
Becker et al. use live imaging of SARS-CoV-2 infected airway epithelium cultures to demonstrate a dual role for mucociliary clearance in viral spread. Initially, virus goes with the mucus flow ...