Its lead asset is PIPE-791, a novel, brain penetrant, small molecule inhibitor of the lysophosphatidic acid 1 receptor (LPA1R) for the treatment of idiopathic pulmonary fibrosis and progressive ...

into a signalling molecule known as lysophosphatidic acid (LPA). These signals can induce various responses along multiple cellular signalling pathways that lead to a build up of fibroblasts.

Survival of multicellular organisms depends on their ability to fight infection, metabolize nutrients, and store energy for times of need. Unsurprisingly, therefore, immunoregulatory and metabolic ...