The dynamics of protein structures are crucial for understanding their functions and developing targeted drug treatments, particularly for cryptic binding sites. However, existing methods for ...
Inactive conformations of protein kinase catalytic domains where the DFG motif has a “DFG-out” orientation and the activation loop is folded present a druggable binding pocket that is targeted by ...
Mechanosensory transduction (MT), the conversion of mechanical stimuli into electrical signals, underpins hearing and balance and is carried out within hair cells in the inner ear. Hair cells harbor ...