In Nijmegen, Netherlands, researchers have installed the world's first microscope capable of live imaging of biological ...

Research Questions: Investigating the mechanism of Cav-1/FGF2 axis-mediated endothelial-mesenchymal transition in aortic valve calcification. Methods: Histopathology, immunohistochemical staining, and ...

Introduction: Fibrocalcific remodeling is an end-stage feature of bioprosthetic (BP) structural valve degeneration and calcific aortic valve (AV) disease. However, the processes governing BP ...

In patients greater than age 65, more than 90% of aortic stenosis involves trileaflet valves which have developed heavy calcification. [5] In these instances the calcium deposits are thought to ...

A new microscope is capable of live imaging of biological processes in such detail that moving protein complexes are visible.

Credit: Thinkstock Routine patient information, serology results, and cardiac ultrasound findings can identify patients at high risk for severe coronary artery calcification. Investigators have ...

smoking and male gender have been identified as the risk factors for both calcific valve disease and atherosclerosis.5 The pathophysiology of aortic calcification is similar to that of atherosclerosis ...

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Calcium deposits can be caused by things like infection, aging, or medical treatments like surgery or cancer therapy. They occur when calcium builds up in soft tissues, where it isn't supposed to be.

With fibrosis of the cardiac skeleton there is calcification at the base of the aortic valve and damage to the His bundle as it perforates the right fibrous trigone. Finally there is decreased ...