Perhaps, not widely known by PC users, there is an option to boot from a USB drive within a running Windows OS installation. If Fast Boot is enabled in UEFI/BIOS, you may not be able to boot from ...
Also, make sure to create a restore point of your computer before making any registry changes. Double click to edit it. Set 1 to turn on notification for USB issue, and 0 (Zero) to turn it off.