It remains unclear why some tumor types do not respond to immune checkpoint blockade (ICB) therapies. Researchers at KU Leuven investigated CD8 + T cell functionality across different tumor types to ...

Here the authors show that high expression of MCT11 is key to the dysfunctionality associated with exhausted CD8 + T cells in tumors. By targeting MCT11, uptake of lactic acid, which is abundant ...

Researchers from the Josep Carreras Leukaemia Research Institute have found that the efficacy of varni-cel, a CAR-T infusion ...

We set out to identify genes that are commonly expressed in CD8 + T cells, killer immune cells that can drive anti-tumor immunity, across many types of human cancers. Our goal was to uncover new ...

Researchers found that methylmalonic acid treatment significantly reduced the activity of CD8 + T cells, an important component of the immune response to tumors. The study's results indicate that ...

Study: The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8 + T cells against cancer. Image Credit: ART-ur/Shutterstock.com ...

which studies how T cells interact in cancer, autoimmunity, and infection, discovered a role for CD4 T cells in helping to overcome CD8 T-cell dysfunction that has opened a door to new targeted ...

A new immune cell biomarker has been discovered that can predict the effectiveness of immune anticancer treatment in patients ...

including CD4/CD8 T cells, regulatory T cells, NK cells, and innate immune cells - Applications to a growing list of autoimmune conditions and cancer types - Effects and responses in treated patients ...

【导读】RNA甲基化是决定免疫细胞功能的重要调节过程，但它如何影响CD8 T细胞的抗肿瘤活性，尚不完全清楚。在这项研究中，团队展示了N6-甲基腺苷 （m6A）RNA读取器YTHDF2在早期效应器或效应器样CD8 T细胞中高度表达。2024年11月5日 ...

A new study has found a surprising link between high levels of methylmalonic acid and the weakening of CD8+ T cells, shedding light on potential pathways through which aging may promote lung cancer ...