Immunofluorescence experiments with anti-TDP-43 antibodies identified the protein in affected cortical regions of patients with FTLD types 1, 2 and 3, in two families with chromosome-17-associated ...

These observations open the door to more in-depth investigations looking into a potential mechanistic link between TMEM106b aggregation and pathological processes in neurodegeneration,” Rothstein ...

A telltale sign of ALS is the buildup of a nucleus-bound gene-expression regulatory protein – TDP-43 – in the cytoplasm of ...

New research examining the skeletal muscle cells of patients with inclusion body myositis (IBM) has revealed that the nucleic acid-binding protein TDP-43, which is normally restricted to the ...

The study was published on October 31, 2024, in Neuron. A protein called TDP-43 is usually located in the nucleus of motor ...

Almost all cases of ALS and half of frontotemporal dementia (FTD) cases are linked to dysfunction in a protein TDP-43.

A new type of degenerative brain disease, limbic-predominant age-related TDP-43 encephalopathy (LATE), was recognized just a ...

Trace Neuroscience Launches with $101 Million Series A Financing to Expand Genomic Medicine for Neurodegenerative Diseases, ...

Researchers have uncovered a mechanism that may trigger ALS’s earliest stages, identifying proteins that mislocalize, causing ...

Approximately 5,000 people in the U.S. develop amyotrophic lateral sclerosis (ALS) each year. On average, they survive for only two to five years after being diagnosed, according to the Centers for ...

recognizes 43kDa TARDBP only when phosphorylated at Serines 409 and 410; stains ubiquitin-positive inclusions in FTLD-U and ALS without nuclear staining; does not stain ghost tangles and ...

▎药明康德内容团队编辑Trace Neuroscience公司今日宣布完成了由Third Rock Ventures领投、Atlas Venture、GV和RA Capital Management参投的1.01亿美元A轮融资。该公司正在开发创新反义寡核苷酸（ASO）疗法，通过恢复UNC13A蛋白功能，以重新建立受神经退行性疾病影响的神经和肌肉细胞之间的信号传导。Trace Neuroscienc ...