Rheb, a small GTPase inhibited by TSC2, positively regulates mTORC1 activity ... Atg13, Autophagy-related protein 13; DAP1, Death-associated protein 1; Deptor, DEP domain-containing mTOR-interacting ...
If the hypothesis is supported, then RHEB knockdown should eliminate the cell size effect of Dyrk1a overexpression. We thank the reviewer for suggesting this experiment. We have overexpressed DYRK1A ...
Here, we describe how the extracellular signal-regulated kinase (ERK) pathway in osteoblasts controls bone formation by suppressing the mechanistic target of rapamycin (mTOR) pathway. We also show ...