uhnresearch.ca Objectives Mammalian target of rapamycin (mTOR) (a serine/threonine protein kinase) is a major repressor of autophagy, a cell survival mechanism. The specific in vivo mechanism of mTOR ...

Rheb, a small GTPase inhibited by TSC2, positively regulates mTORC1 activity ... Atg13, Autophagy-related protein 13; DAP1, Death-associated protein 1; Deptor, DEP domain-containing mTOR-interacting ...

Proteotoxic stress impairs cellular homeostasis and underlies the pathogenesis of many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). The proteasomal and autophagic ...

The Ras/Ral pathway is less kinase-dependent than other Ras effector pathways, although there has previously been discussions of cross-talk between the Ral and PI3K pathway, through activation of mTOR ...

The sperm epigenome is shaped in a compartment protected by the blood-testes barrier (BTB) known to deteriorate with age. Permeability of the BTB is regulated by the balance of two mTOR complexes in ...