01.069.0, UMC Utrecht, Location WKZ, Lundlaan 6, 3584 EA Utrecht, The Netherlands; B.Prakken{at}umcutrecht.nl Objectives: To explore potential T-cell epitopes of the core protein of human cartilage ...

Glypican members of the heparan sulphate proteoglycan family regulate several developmental signalling pathways, such as those involving Hedgehog, Wnt, BMP and FGF. Two studies reveal opposite ...

This work is an important contribution to understanding the role of FGF signaling in the induction of primitive-like cells in a 2D system of human gastrulation. The authors provide compelling evidence ...

Although it is well established that proteoglycans are required for FGF signalling, it was not known whether cells can regulate proteoglycan synthesis through glucose metabolism as a strategy to ...

信号传导所需的蛋白聚糖（proteoglycan）的形成。这种信号传导对细胞分化和原始条纹（primitive streak）延伸至关重要。这种结构最终形成神经板 ...

1 Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands 2 Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands 3 Institute of Anatomy ...