This study investigates the critical role of epigenetic PPARγ (peroxisome proliferator–activated receptor-gamma) suppression in OA development. Methods Articular cartilage expressions of PPARγ and ...

Setonix Pharmaceuticals has described peroxisome proliferator-activated receptor γ (PPARγ) modulators reported to be useful for the treatment of inflammatory disorders, metabolic syndrome, obesity, ...

This landmark study elucidates the intricate structural mechanisms by which both covalent and non-covalent synthetic ligands can co-occupy the binding pocket of the nuclear receptor transcription ...

uhnresearch.ca Objectives Mammalian target of rapamycin (mTOR) (a serine/threonine protein kinase) is a major repressor of autophagy, a cell survival mechanism. The specific in vivo mechanism of mTOR ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Tumor-associated macrophages (TAMs) are prime ...

School of Pharmacy, Guangxi University of Chinese Medicine, No. 13, Wuhe Avenue, Nanning, Guangxi 530200, China ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.

1 Luoyang Key Laboratory of Cardiovascular Science, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China 2 Department of ...

Mitochondrial dysfunction, characterized by impaired lipid metabolism and heightened reactive oxygen species generation, results in lipid peroxidation and ferroptosis. Ferroptosis is an inflammatory ...

1 Department of Pharmacy, Public Health Clinical Center of Chengdu, Chengdu, Sichuan, China 2 Scientific Research and Teaching Department, Public Health Clinical Center of Chengdu, Chengdu, Sichuan, ...