Research shows mitochondria form distinct subpopulations under nutrient stress, revealing survival mechanisms in cancer cells ...

In a recent publication in Nature Communications, researchers from the Tumor Profiler consortium combined single-cell multi-omics and functional profiling for 21 AML patients to reveal resistance ...

Researchers from the Tumor Profiler consortium have combined single-cell multi-omics and functional profiling for 21 AML ...

Acute-on-chronic liver failure (ACLF) is a life-threatening condition characterized by acute deterioration of liver function ...

Metabolism in ACLF Metabolic reprogramming is a central feature of ACLF. In immune cells, the metabolic pathways shift from oxidative phosphorylation (OXPHOS) to glycolysis, the pentose phosphate ...

Nematodes can sniff out trouble, kicking off a mitochondrial defense in the gut to fend off bacterial invaders.

A recent study offering a comprehensive view of the genome and transcriptome of gastrointestinal stromal tumors (GISTs) has ...

In humans, the main molecular energy carrier is adenosine triphosphate (ATP). It is critical for cellular functions all over the body, especially in the brain. Its synthesis, which occurs in the ...

However, eIF-2α phosphorylation remains crucial for managing ER stress and ensuring normal ... during aging could reveal new targets for extending lifespan and improving stress resilience in older ...

Goodman and Bellen place this subpar response to oxidative stress upstream in the AD cascade, when tau phosphorylation begins and ROS start to accumulate. Complicating this scenario, AD risk factors, ...