Deoxynucleoside analogues such as 5-aza-2-deoxycytidine (depicted by Z) are converted into the triphosphate inside S-phase cells and are incorporated in place of cytosine into DNA. Ribonucleosides ...

Generally, the dual NRTI backbone treatment of combination with a non-NRTI (NNRTI) or protease inhibitor (PI) should comprise a cytidine analogue (lamivudine, emtricitabine) and a thymidine ...

Researchers have found a new way to use biocatalysis to improve the production of critical raw materials required for ...

Researchers have found a new way to use biocatalysis to improve the production of critical raw materials required for ...

Inosine is a nucleoside that occurs naturally in transfer RNAs (tRNAs) and is essential for proper RNA translation. It is commonly found at the wobble position of anticodons, allowing for greater ...

(A) Nucleoside triphosphates serve as a substrate for DNA polymerase, according to the mechanism shown on the top strand. Each nucleoside triphosphate is made up of three phosphates (represented ...

Specific subtypes and transmission clusters for HIV could require targeted interventions to control spread of HIV that is ...

Imbalances in pyrimidine biosynthesis can lead to various disorders, such as orotic aciduria and pyrimidine nucleoside phosphorylase deficiency. Some pyrimidine analogs, such as azidothymidine (AZT) ...