Analysis of human brain tissue revealed differences in how immune cells behave in brains with Alzheimer's disease compared to ...

Researchers have created a highly detailed cellular map of Alzheimer’s disease progression, revealing new insights into the ...

One commonality across neurodegenerative diseases is sustained neuroinflammation, mediated in large part by microglia, the innate immune cells of the brain. Initially thought to simply react to neuron ...

“Together, these results suggest that microglia are being activated by human neuron–produced APOE4 and, in turn, are ...

Their research is published in the journal Nature Communications. Stroke negatively influences interaction of microglia and neurons The vasculature, that is, the system of blood vessels of the SVZ ...

In healthy brains, immune cells called microglia patrol for damage, clearing away debris and harmful proteins. But in the presence of the APOE4 protein—the most important genetic risk factor for ...

Research from the College of Medicine provides promising insights into delaying the progression of Alzheimer’s disease for ...

"Together, these results suggest that microglia are being activated by human neuron–produced APOE4 and, in turn, are potentially helping form the misfolded protein aggregates we see in Alzheimer ...