NLRP3 is an inflammasome seeding pattern recognition receptor activated in response to multiple danger signals which perturb intracellular homeostasis. Electrostatic interactions between the NLRP3 ...

8月30日，中山大学李轩教授团队在期刊《Journal of Experimental & Clinical Cancer Research》上发表了研究论文，题为“Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME ...

Gasdermins (GSDMs) 家族蛋白能够引起细胞焦亡，在抵抗病原感染方面发挥重要作用。人源GSDMs 家族成员包括 GSDMA、 GSDMB、 GSDMC、 GSDMD、 GSDME。这些保守蛋白都是由N端打孔结构域（pores-forming domain）和C端自抑制结构域（repressor domain）组成的。静息状态下, GSDMs家族蛋白 ...

JNK regulation of GSDMD and GSDME leads to cellular pyroptosis, which in turn causes aging. Apoptosis signal-regulated kinase 1 (ASK-1) promotes the activation of JNK, which further converts proIL-1β, ...

The predicted structures of GSMD family (GSDMA to GSDME) are displayed at orient axes ... NET, Neutrophil extracellular trap; NLRP3, NOD-like receptor family pyrin domain containing 3; NMDAR, N-methyl ...