尽管抗PD1疗法对肝细胞癌（HCC）患者疗效显著，但大多数患者出现耐药性。 2024年11月4日，复旦大学Dai Zhi唯一通讯在Cellular & Molecular Immunology在线发表题为“Targeting GSDME-mediated macrophage polarization for enhanced antitumor immunity in ...

Conclusion Our immunoepigenetic strategy harnesses IFNγ-mediated network to augment the cancer-immunity cycle, revealing a self-reinforcing STAT1-GSDME pyroptotic circuitry as the mechanistic basis ...

is recognized for its diverse biological functionalities, in particular alleviating myocardial ischemia-reperfusion injury (MIRI). There is ample evidence suggesting that the NLRP3 inflammasome has a ...

This study presents an important finding on the involvement of a Caspase 3-dependent pathway in the elimination of synapses for retinogeniculate circuit refinement and eye-specific territory ...

Inactivation of retinogeniculate synapses induces caspase-3 activity. In the mouse retinogeniculate pathway, retinal ganglion cells (RGCs) in the retina of each eye innervate relay neurons in both the ...