【导读】越来越多的证据，强调了免疫机制调节在建立和维持理想免疫治疗结果所需的肿瘤特异性细胞毒性方面的重要性。然而，机械生物学输入和输出与指定免疫活动之间的分子联系，在很大程度上仍不清楚。在这项研究中，团队表明非肌肉肌球蛋白II（NM ...

No biological system has been studied by more diverse approaches than the actin-based molecular motor myosin. Biophysics, biochemistry, physiology, classical genetics and molecular genetics have ...

大型学术专著《狂犬病(RABIES)》第9章的译文(8)前记: 目前国际上关于狂犬病研究最权威最全面的大型学术专著是《狂犬病的科学基础和管控（RABIES: SCIENTIFIC BASIS OF THE DISEASE AND ITS ...

真核细胞依赖形态的动态变化来执行多种功能，以维持基本生物过程并调控细胞行为。单细胞捕食性原生动物——长吻虫，其形态与天鹅相似，其中常见种天鹅长吻虫（Lacrymaria ...

乳酸是体内代谢调控的支点，在心脏肥大、损伤和心力衰竭中发挥重要作用，乳酸是心脏的重要能量底物，α-肌球蛋白重链（α-MHC）与Titin的肌节相互作用对心脏结构和收缩至关重要。然而，在正常和衰竭的心脏中，调节这种相互作用的机制仍然未知。 2023年7月，中国医科大学附属第一医院孙英贤教授团队在Cell Research（IF=28.1）上，发表“α-myosin heavy chain lacty ...

Here we demonstrated that INAD bound directly to the NINAC myosin III, yet the subcellular localization of NINAC was normal in inaD mutants. Nevertheless, the INAD binding site was sufficient to ...

Recently, a research team has collaborated to propose a deep learning model for predicting protein conformational changes.

The drug Cytokinetics is placing its hopes on is aficamten, a selective small-molecule inhibitor of cardiac myosin. The drug ...

Non-muscle myosin 2 is a motor protein involved in many cellular processes, most notably cell motility and contraction, which allows a cell to crawl and reorganize organelles within itself. To achieve ...

Eggs pop out of ovaries. But what propels them has been unknown. Now, researchers from the University of Connecticut explain in an article published in the September 18 issue of the Proceedings of the ...

The actin motor protein nonmuscle myosin II is enriched at vertical borders between neighboring cells along the A-P axis, which may prevent cells from moving in the wrong direction. Conversely, the ...

A new report from cultivated meat co SuperMeat offers proof that with the right tech there is a "commercially viable path to ...