CONTEXT: Xiaojianzhong decoction (XJZD), classically prescribed in Chinese medicine, has protective and healing effects on gastric mucosal injury. However, the exact mechanism behind this effect ...

We found it is an activator of PHLPP1, a critical phosphatase in the conserved AMPK/mTOR signaling networks implicated in hibernation and fuel sensing (O 2, glucose, amino acids). We synthesized it ...

These pathways include the CaMKII, AMPK, mTOR, and IRS1/PI3-K/AKT/GLUT4 pathways, each playing a unique role in glucose metabolism and insulin sensitivity. Figure 2. Mechanisms of the benefits of ...

Furthermore, we show that regulation of ULK1/adenosine monophosphate-activated protein kinase (AMPK) signalling pathway by mTOR may in part be responsible for regulating autophagy signalling and the ...

Antibodies against phospho‐mTOR (Cell signal, 2971), mTOR (Cell signal ... We previously showed that global Sesn2 knockout mice are more prone to I/R injury, and that Sesn2 may regulate AMPK and ...

Development of therapies that specifically target the AMPK–HNF4α–WNT signal cascade would probably represent effective ... cPARP, t-caspase 3, c-caspace 3), t-mTOR, p-mTOR (Ser 2448 and Ser2481), ...

Mechanistically, metformin treatment upregulated p-AMPK (phosphorylated AMP-activated protein kinase) and downregulated p-STAT3 (phosphorylated signal transducer and activator of transcription 3) ...

MTOR is present in two different protein complexes, mammalian target of rapamycin (mTORC1) and mTORC2, but only mTORC1 has a role in regulating autophagy (13). Activated ULK1 complex phosphorylates ...

Skeletal muscle is a vital organ for maintaining health. In this article, we explore how protein feeding and exercise ...

Cancer remains one of the leading global causes of mortality, with an estimated increase in cases due to lifestyle, ...