We found it is an activator of PHLPP1, a critical phosphatase in the conserved AMPK/mTOR signaling networks implicated in hibernation and fuel sensing (O 2, glucose, amino acids). We synthesized it ...

Development of therapies that specifically target the AMPK–HNF4α–WNT signal cascade would probably represent effective ... cPARP, t-caspase 3, c-caspace 3), t-mTOR, p-mTOR (Ser 2448 and Ser2481), ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.

【导读】本研究旨在探讨联合使用二甲双胍和辛伐他汀疗法对脑胶质瘤恶性进展的抑制作用。11月9日，中国科学技术大学研究团队在期刊《Cell Death&Disease》上发表了研究论文，题为“Combined metformin and ...