2024年11月1日，北京大学生命科学学院和北大-清华生命科学联合中心胡家志课题组及合作者在Nature Communications发表了标题为“Transfer of mitochondrial DNA into the nuclear ...

Mitochondrial genome mutations may be linked to ALS, per a study, opening the door for new ways to diagnosing and treating ...

What happens to your cells when this DNA mutates? Similar to the nuclear genome, the mitochondrial genome is built of double-stranded DNA, and it encodes genes (Figure 2). However, the ...

Geneticists looking inside the nuclear genome for mutations that contribute to disease have long relied on a principal known ...

Progress in this field has greatly benefited from the human genome project and from knowledge obtained from lower species. Recent technical advances in mouse mitochondrial genetics have enabled ...

"We noted that our study was the first to associate mitochondrial genome mutations with ALS. We conducted an interesting ...

“We noted that our study was the first to associate mitochondrial genome mutations with ALS. We conducted an interesting analysis based on a quantitative approach. It’s hard to obtain a large sample ...

Though fully integrated cellular organelles, the mitochondria never entirely lost their primordial genome, known today as mitochondrial DNA (mtDNA). Today mtDNA produces 13 key mitochondrial proteins.

as with the mitochondrial genome or the chloroplast genome. Additionally, the genome can comprise nonchromosomal genetic elements such as viruses, plasmids, and transposable elements. When people ...

Chromosomes are the fundamental structural units of our genome. The Sfeir lab seeks to understand basic chromosome biology and how their mismanagement manifests in disease. Our research is focused on ...