For example, researchers have found mutations of the MTHFR gene, or methylenetetrahydrofolate reductase, to be linked to conditions like depression, bipolar disorder, certain cancers, and high ...

We also estimated gestational FA supplementation via surveys and genotyped the maternal MTHFR 677C>T single nucleotide polymorphism (SNP). We estimated the confounder-adjusted associations between ...

Polymorphisms in genes encoding proteins in two major cellular pathways influenced by MTX, namely the folate and adenosine pathways, and their association with response to MTX have been examined ...

A total of 124 RA patients, 101 (81.5%) women and 23 (18.5%) men, treated with MTX in monotherapy, were enrolled in this study. They had taken 0–3 DMARDs prior to treatment with MTX. Ninety-five ...

p53 lies at the hub of a vast signalling network. Polymorphisms in upstream activators, repressors or downstream effectors of p53 might individually modulate cancer risk or interact with ...