尽管抗PD1疗法对肝细胞癌（HCC）患者疗效显著，但大多数患者出现耐药性。 2024年11月4日，复旦大学Dai Zhi唯一通讯在Cellular & Molecular Immunology在线发表题为“Targeting GSDME-mediated macrophage polarization for enhanced antitumor immunity in ...

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Conclusion Our immunoepigenetic strategy harnesses IFNγ-mediated network to augment the cancer-immunity cycle, revealing a self-reinforcing STAT1-GSDME pyroptotic circuitry as the mechanistic basis ...

Two years after emerging with its initial funding round, CDMO Nucleus RadioPharma is going bicoastal, revealing expansions at two sites that the company believes will "significantly improve ...

Nucleus RadioPharma, co-founded by Mayo Clinic, plans to build facilities in Mesa, Arizona and Springhouse, Pennsylvania. The start-up is also creating a manufacturing center in downtown Rochester ...

The nucleus is the double membrane limited structure within an eukaryotic cell that contains the chromosomes, and where the DNA is replicated or transcribed into RNA. The membrane is perforated by ...

Last season, the Mavericks finished three wins shy of clinching the franchise’s second NBA championship after a hard-fought Finals matchup against Boston. Eager for another NBA Finals berth ...

For many years, scientists believed that fundamental particles like protons and neutrons that form an atomic nucleus, can’t be divided further into smaller units. However, in the following years ...

Sepsis represents a severe condition characterized by organ dysfunction resulting from a dysregulated host response to infection. Among the organs affected, the kidneys are particularly vulnerable, ...