Conclusion Our immunoepigenetic strategy harnesses IFNγ-mediated network to augment the cancer-immunity cycle, revealing a self-reinforcing STAT1-GSDME pyroptotic circuitry as the mechanistic basis ...

ISLAMABAD: Two ben­c­hes of the Islamabad High Court (IHC) issued contrasting rulings on identical cases concerning access to imprisoned former prime minister Imran Khan. IHC Chief Justice Aamer ...

The Islamabad High Court (IHC) on Thursday ordered jail authorities to produce former prime minister and PTI founder Imran Khan by 3 pm, ARY News reported. As per details, Justice Sardar Ejaz ...

ISLAMABAD: The Islamabad High Court (IHC) on Thursday ordered the Adiala jail superintendent to present Pakistan Tehreek-e-Insaf (PTI) founder Imran Khan, who is behind bars, before the court ...

Given recent evidence that pyroptosis, as a new form of programmed cell death, is induced by caspase-3-dependent GSDME (gasdermin E) cleavage, we hypothesized that cathepsin L might promote PH through ...

Here, we demonstrated that ZIKV causes the pyroptosis of placental cells by activating the executor gasdermin E (GSDME) in vitro and in vivo. Mechanistically, TNF-α release is induced upon the ...