Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210 United States ...

Fibroblasts from PLNR9C hearts with DCM had elevated ROS levels (Amplex Red assay 2.5-fold, p<0.01, n=3) and displayed a senescent phenotype, with elevated levels of the senescence markers p16 ...

Senescence is the process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing cell death. Senescence can be induced by unrepaired DNA damage ...

Some scholars have proposed that cellular senescence may be the driver of skin aging. Intrinsic aging involves reduced cell replication, affecting keratinocytes, fibroblasts, and melanocytes in the ...

The research focuses on cellular senescence, a process where cells ... advanced sequencing and bioinformatics analyses on ...

Subsequently, the function and molecular mechanism of GKN1 was explored in vitro and in vivo. Results It was shown that GKN1 is an autocrine/paracrine protein and inhibits cell growth due to ...

The process of cellular senescence and the development of the senescence-associated secretory phenotype (SASP) is believed to lead to chronic inflammation, chronic illnesses, as well as accelerated ...

Objectives Myofibroblasts are key effector cells in the extracellular matrix remodelling of systemic sclerosis-associated interstitial lung disease (SSc-ILD); however, the diversity of fibroblast ...

The research focuses on “cellular senescence,” a process where cells stop dividing and enter a state associated ... This discovery was made using advanced sequencing and bioinformatics analyses on ...