Aims: To determine the maximum tolerated dose (MTD), safety and anti-tumor activity of afatinib combined with docetaxel in advanced cancer. Patients & methods: The MTD was determined from dose ...

The ERBB receptors are a group of receptor tyrosine kinases (RTKs) involved in key cellular functions including cell growth and survival. What are the activation mechanisms particular to ERBBs?

ERBB receptors are regulated by their own intrinsic properties as well as by external associated proteins. What is regulation, where does it occur on the receptor, and how do scientists study it?

American Green, Inc. operates as a technology company in the medical cannabis industry in the United States. It develops retail, brand, and commercial cultivating solutions in partnership with ...

The ErbB family (HER-1, HER-2, HER-3 and HER-4) of receptor tyrosine kinases has been the focus of cancer immunotherapeutic strategies while antiangiogenic therapies have focused on VEGF and its ...

在这项研究中，Mitchell A. Lazar等人通过在成年小鼠肝细胞中特异性删除昼夜节律调节基因REV-ERBa、REV-ERBb，构建了肝脏分子钟紊乱的小鼠模型（HepDKO）。他们打算通过让肝脏与大脑的生物钟“错位 ...

THRAP3, STMN1, and GNA13—are overrepresented in blood cancers like acute myeloid leukemia (AML) and could prove to be novel ...

Professor of developmental biology and former member of the Nobel Assembly Björn Vennström has passed away at the age of 75. He is survived by his ...

【导读】胆囊癌（GBC）是一种高度侵袭性的恶性肿瘤，目前临床上缺乏可用的靶向治疗药物。11月4日，上海交大与浙江大学研究人员合作共同在期刊《Advanced Science》上发表了研究论文，题为“Super-Enhancer ...

Tetsu Narumi,Kazuhiko Fukui, Takaho Terada, Makoto Taiji, Mikako Shirouzu, Shigeyuki Yokoyama, and Akihiko Konagaya: "Molecular Dynamics, Free Energy, and SPR Analyses of the Interactions between the ...