thus reducing ECM degradation (Lin et al., 2021). These studies provide valuable insights into the role of autophagy in OA pathogenesis, and offer promising avenues for the development of novel ...

Until today, there are limited success in treating OA or restoring cartilage function. Cartilage aging is associated with concomitant changes in both chondrocyte activities and extracellular matrix ...

ROS further exacerbate ECM degradation by activating matrix metalloproteinases (MMPs ... By incorporating bioactive molecules that regulate mitochondrial dynamics, these hydrogels restore cellular ...

The term osteoarthritis refers to a group of disorders that result in the primarily mechanically induced structural and functional failure of synovial joints. Osteoarthritis is considered a risk ...

This fundamental study generated a single cell atlas of mouse periosteal cells under both steady-state and fracture healing conditions to address the knowledge gap regarding cellular composition of ...

This important study characterizes various cell populations and describes a developmental trajectory using snRNAseq data, highlighting the cell state transitions including periosteal stem cells during ...

Correspondence to Dr Zhiqi Zhang, Department of Joint Surgery, Sun Yat-sen University First Affiliated Hospital, Guangzhou 510080, China; zhzhiqi{at}mail.sysu.edu.cn; Dr Weiming Liao; ...

The synovium consists of two layers, lining and sublining. The sublining is composed of Thy1+ fibroblasts, immune cells, blood vessels and nerves in a meshwork of extracellular matrix (ECM). The ...

Institute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an ...