The nuclear genomes of most higher eukaryotic organisms are diploid and are characterized by disomic inheritance and sexual reproduction. So, nuclear genes come in allelic pairs that are often ...

Flow cytometry compared the cellular compositions of trisomic and disomic fetal livers. Characterizing the epigenome of single hematopoietic cells in trisomy fetal liver revealed gene-regulatory ...

Specifically, they have preliminary data that the Dp16 mice (one mouse model of Down syndrome) have sleep abnormalities (like DS individuals) corrected in part by deleting one of three copies of RCAN1 ...