Cancer continues to be one of the most challenging diseases due to the complex molecular mechanisms involved. Epigenetic modifications, particularly histone modifications, play a crucial role in ...

Epigenome editing demonstrates that DNA methylation can impact certain histone marks, helping control proper gene expression dynamics. Here the authors show that DNA double-strand breaks move ...

Plasma samples were assessed for NET markers, including cell-free DNA (cfDNA) and histone-DNA complexes, along with DNase ...

Portal vein thrombosis (PVT) is a challenging complication in liver cirrhosis, with no currently available sensitive ...

The good news is that drugs called CHK1 inhibitors were found to selectively destroy tumor cells containing ecDNA in mice ...

The histone proteins of complex cells are named H2A, H2B, H3 and H4. They are assembled into groups of eight, around which a ...

The most popular of these treatments aim to alter either DNA methylation or histone acetylation. Inhibitors of DNA methylation can reactivate genes that have been silenced. Two examples of these ...

Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 77 Pollock Rd, University Park, Pennsylvania 16802, United States Artie ...

A new study claims that air pollution breathed in by women during pregnancy may possibly be linked to a greater risk of their ...

Histones are not only essential for packaging and DNA into a compact form called chromatin ... have which chemical modifications, where on the histone protein those modifications occur, and ...

An understanding of the enzymatic and scaffolding functions of epigenetic modifiers is important for the development of epigenetic therapies for cancer. The H3K4me2/3 histone demethylase KDM5C has ...