FIC1 disease collectively refers to a group of autosomal-recessive familial liver disorders characterized by intrahepatic cholestasis due to mutations in the ATP8B1 gene (initially named FIC1).

Children with cholestatic liver disease are at risk for developing secondary vitamin K deficiency because of fat malabsorbtion and inadequate dietary intake. In this study, we described 11 infants ...

Drug-induced liver injury including cholestasis is another form of acquired liver disease, accounting for approximately 2 to 5% of hospitalizations for jaundice, 10% of cases of hepatitis in all ...

Ursodeoxycholic acid (UDCA) is widely used for the treatment of chronic cholestatic liver diseases. However, a recent randomized, controlled trial has surprisingly shown that the use of high-dose ...

This study examined the natural history of infants born with alpha-1 antitrypsin (AAT) deficiency and liver disease ... by too few bile ducts resulting in cholestasis, can damage not only the ...

Bilirubin, the byproduct of hemoprotein breakdown, particularly hemoglobin, is a critical marker in diagnosing, prognosing, ...

Peking University-led researchers have modified an existing treatment for liver disease that does not cause itchiness, a ...

Ipsen announced today that the National Institute for Health and Care Excellence (NICE) has recommended elafibranor 80mg ...

▎药明康德内容团队编辑  皮肤没长什么东西，却莫名其妙地反复瘙痒，在夜晚格外严重，甚至痒得睡不着觉；身上挠出一道道印子，用了很多护肤品、止痒药也没什么效果……对于很多肝胆疾病导致胆汁淤积的患者来说，这样难以忍受的全身性瘙痒常常发生，极大地影响了生活质 ...

Bilirubin, the byproduct of hemoprotein breakdown, particularly hemoglobin, is a critical marker in diagnosing, prognosing, and managing liver ...

Addressing the challenge of cholestatic itch, the scientific community has been pursuing innovative solutions. Recently, researchers from Peking University, led by Professor Lei Xiaoguang, in ...

Mirum Pharmaceuticals, Inc. is a biopharmaceutical company dedicated to transforming the treatment of rare diseases affecting ...