GEN1 小时
Checkpoint Inhibitors May Be Improved by Metabolic Reprogramming of T Cells
Stimulating a key metabolic pathway in T cells can make them work more effectively against tumors when combined with immune ...
生物谷10 天
后PD-1时代，免疫联合治疗的「得」与「失」
CAR-T细胞在血液瘤中的成功尚未转化为实体肿瘤 ... 共享新抗原和个体化新抗原）、非突变共享抗原的相对作用，以及在这种情况下CD4+ T细胞和CD8+ T细胞的激活作用，各种问题仍然存在。2024年7月，BioNTech宣布，BNT111+西米普利单抗在晚期黑色素瘤的II期临床试验 ...
Metabolic reprogramming of T cells may enhance checkpoint inhibitor therapy
Stimulating a key metabolic pathway in T cells can make them work more effectively against tumors when combined with immune ...
GEN11 天
Improving CAR-T Cell Efficacy via New Manufacturing Process
A new bioprocessing technique developed by a team of researchers could improve a range of therapies based on CAR-T cells.
Targeted Oncology7 天
Lunning Evaluates CAR T-Cell Therapy for ASCT-Eligible and Ineligible DLBCL
During a Case-Based Roundtable® event, Matthew A. Lunning, DO, discussed the updated trial data for 2 chimeric antigen ...
来自MSN10 天
结直肠癌免疫治疗的现状和挑战
OV-CD19T和CD19-CAR-T联合治疗在体外和体内都是一种安全有效的治疗实体瘤的方法，提示具有持久的肿瘤杀伤作用。 癌症免疫疫苗 含有TAAs或肿瘤特异性抗原（TSA）的治疗性癌症疫苗可直接刺激免疫系统，激活CD4+和CD8+T细胞以杀死肿瘤。已经开发出许多癌症疫苗 ...
Mena FN5 天
DELTAREX-G FOR CAR-T CELL THERAPY INDUCED CYTOKINE RELEASE SYNDROME
Haroun stated“This theory is supported by the inhibitory activity of DeltaRex-G in transduced CD4+ CD8+ cell cultures. DeltaRex-G may be used to treat CRS by inhibiting a certain proportion of the ...
MedPage Today10 天
Turning 'Cold' Tumors Into 'Hot' Tumors
"Hot tumors tend to have a greater number of lymphocytes, in particular T cells, certainly CD8 but probably also CD4, cells that are specific for various antigens in the ... that have potential to ...