Researchers from the Josep Carreras Leukaemia Research Institute have found that the efficacy of varni-cel, a CAR-T infusion ...

A new phase 1 trial demonstrates the safety and effectiveness of personalized neoantigen DNA vaccines, showing promising ...

The development of CAR-T technology in recent years has been a major milestone in the fight against cancer. These sort of ...

Researchers at Winship Cancer Institute of Emory University have identified a novel type of immune cell, called the stem-like CD4 T cell, that plays a pivotal role in anti-tumor immunity.

The stem-like CD4 T cells have the ability to renew themselves and transform into different immune cell types. These cells are marked by two specific proteins, PD1 and TCF1, which help determine ...

T cells are white blood cells that are important for adaptive immunity. They have unique cell surface receptors that are generated by randomly assorting genes. These receptors allow T cells to ...

“The impaired numbers of CD3 + T cell may contribute to a weakened anti-tumor response, potentially leading to a poorer prognosis ... The number of IgG, B-lymphocytes, CD4/CD8, CD4 + T-lymphocytes, ...

which studies how T cells interact in cancer, autoimmunity, and infection, discovered a role for CD4 T cells in helping to overcome CD8 T-cell dysfunction that has opened a door to new targeted ...

It can restart a powerful anti-tumor immune response and enhance responsiveness to PD1 blockade in animal models." The findings suggest that almost all patients have this stem-like CD4 T cell in ...

Memory CD8 + T cells are the mature version that has encountered an antigen before and create an immune response if it is reencountered. Lower levels of apoptosis were also seen in the CD4 + T ...