It uses a gram-positive intracellular bacterium to trigger strong CD4 and CD8 T cell responses. The vaccine also expresses signs of tumors, which makes tumor-reactive T cells more sensitive to signs ...

The development of CAR-T technology in recent years has been a major milestone in the fight against cancer. These sort of ...

“The impaired numbers of CD3 + T cell may contribute to a weakened anti-tumor response, potentially leading to a ... The number of IgG, B-lymphocytes, CD4/CD8, CD4 + T-lymphocytes, and IgM in low-risk ...

Researchers at Winship Cancer Institute of Emory University have identified a novel type of immune cell, called the stem-like CD4 T cell, that plays a pivotal role in anti-tumor immunity.

Tumor tissue and ascites from patients with ovarian cancer contain high levels of cells with all the hallmarks of regulatory T cells. These cells migrate into the tumor microenvironment in a ...

It can restart a powerful anti-tumor immune response and enhance responsiveness to PD1 blockade in animal models." The findings suggest that almost all patients have this stem-like CD4 T cell in ...

T cells are white blood cells that are important for adaptive immunity. They have unique cell surface receptors that are generated by randomly assorting genes. These receptors allow T cells to ...

Both published and newer data suggests that DNase I impedes neutrophil tumor infiltration, promotes CD4 and CD8 T cell infiltration, and enhances intratumoral T cell activation. DNase I plus -CTLA-4 ...